Steve and Toasters
Steve has, many times, run into problems with toasters. This seems to be the result of an unfeasible conspiracy against Steve; every time Steve attempts to make toast, something goes horribly wrong with the toaster. For example, various toasters have turned out to be fairies, Transformer-esque robots, or haunted.
Steve's problems with toast date even further back than these toaster troubles: at one point, Steve attempted to butter his toast only to discover that the butter had become a foul-tasting, three-eyed being.
Removal of Body Parts
Various appendages and body parts are removed frequently in this comic. In one case, an awkward situation arose when Steve discovered Moustache Guy's disembodied nipples while bathing in a hot tub (Comic 20). In another, Beaver somehow obtained another (or possibly the same) man's nose. Beaver once removed Steve's pelvis and used it to escape from the Shoe Goblin's clutches.
Steve's Inner Demons
Steve sometimes struggles with his inner demons, in a very literal sense. Steve's body has been occupied by actual demons who emerge every thousand years, a Lincoln-esque man in a top hat, and Loki, the Norse god of mischief.